Carcinogenesis Models Using Small Fish

Experimental animals are indispensable in life science-related research, including cancer studies. After rats and mice, small fishes, such as zebrafish medaka, the second most frequently used model species. Fish models have some advantageous physical characteristics that make them suitable for their size, transparency, genetic manipulability, ease of handling, highly ortholog correspondence with humans. This review introduces technological advances carcinogenesis production using fish. Carcinogenesis begins chemical carcinogenesis, followed by mutagenesis. Gene transfer technology has made it possible to incorporate various mechanisms act on cancer-related genes individuals. For example, scientists may now spatiotemporally control gene expression a single fish through methods localization an site via tissue-specific promoter light, heat, or substance. In addition, genome editing is realizing more specific efficient disruption than conventional mutagenesis, which interest depends chance. These improved animal will soon create better mimic human pathology. We conclude discussing future expectations research